| Title | Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice |
| Authors | Jing, Li Zhang, Min Li, Jun-Xu Huang, Ping Liu, Qing Li, Yu-Ling Liang, Hui Liang, Jian-Hui |
| Affiliation | Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China. SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA. Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China. Tsinghua Univ, Sch Med, Beijing 100083, Peoples R China. Guangzhou Univ Chinese Med, Coll Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China. Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China. |
| Keywords | Methamphetamine Behavioral sensitization Single-dose injection Repeated-dose injection NEUROCHEMICAL SENSITIZATION MORPHINE EXPOSURE AMPHETAMINE COCAINE EXPRESSION RATS PRETREATMENT INHIBITORS ADDICTION |
| Issue Date | 2014 |
| Publisher | 神经科学快报 |
| Citation | NEUROSCIENCE LETTERS.2014,560,103-106. |
| Abstract | Repeated exposure to drugs of abuse produces a persistent behavioral sensitization to stimulants, which is often used to study drug-associated behavioral plasticity. Interestingly, even a single exposure to some drugs of abuse is sufficient to elicit long-lasting behavioral sensitization. However, few studies have directly compared the magnitude of sensitization between single versus repeated drug treatments. This study examined the magnitude and duration of single methamphetamine (METH) injection-induced behavioral sensitization and compared it to the more typical repeated drug injection-induced sensitization in mice. Different groups of mice were injected with METH (0.5, 1.0, 2.0 mg/kg, i.p.) only once or daily for 7 consecutive days. A challenge dose of METH (1.0 mg/kg, i.p.) was tested 7 days later. The time-course of a single METH injection-induced behavioral sensitization was assessed where METH (2.0 mg/kg, i.p.) was injected and a challenge dose of METH (1.0 mg/kg, i.p.) was tested after different drug-free periods. Single METH injection produced similar magnitude of behavioral sensitization as compared to repeated injection. Such a sensitized locomotor response peaked 8 days after METH injection and lasted for at least 21 days. This long lasting behavioral alteration induced by single METH injection suggests the value of future studies to explore the underlying neural mechanisms, particularly in comparison to those underlying repeated METH-induced sensitization. Published by Elsevier Ireland Ltd. |
| URI | http://hdl.handle.net/20.500.11897/190073 |
| ISSN | 0304-3940 |
| DOI | 10.1016/j.neulet.2013.12.024 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 医学部待认领 |
