| Title | A comparative study between Embosphere (R) and conventional transcatheter arterial chemoembolization for treatment of unresectable liver metastasis from GIST |
| Authors | Gao, Guang Zhu, Xu Li, Jian Shen, Lin Yang, Renjie Chen, Hui Wang, Xiaodong Gao, Song Xu, Haifeng Zhu, Linzhong Liu, Peng Guo, Jianhai |
| Affiliation | Peking Univ, Canc Hosp & Inst, Dept Intervent Therapy, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China. Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China. |
| Keywords | Transcatheter arterial chemoembolization (TACE) gastrointestinal stromal tumor (GIST) embolization GASTROINTESTINAL STROMAL TUMORS HEPATOCELLULAR-CARCINOMA TRANSARTERIAL CHEMOEMBOLIZATION PROGNOSTIC-FACTORS ELUTING BEADS EMBOLIZATION MANAGEMENT SURVIVAL DOXORUBICIN TRIALS |
| Issue Date | 2014 |
| Publisher | 中国癌症研究英文版 |
| Citation | CHINESE JOURNAL OF CANCER RESEARCH.2014,26,(1),124-131. |
| Abstract | Objective: Transcatheter arterial chemoembolization (TACE) is a standard treatment for hepatocellular carcinoma (HCC) and/or some unresectable liver metastasis tumors. Hypervascular liver metastatic lesions such as metastasis from gastrointestinal stromal tumor (GIST) are an indication for transcatheter arterial embolization (TAE). The purpose of this study was to evaluate the efficacy and safety of Embosphere (R)-TAE (Embo-TAE) in comparison with conventional TACE (cTACE) for the treatment of liver metastasis from GIST. Methods: A total of 45 patients who underwent TACE between Aug 2008 and Feb 2013 were enrolled. Patients with GIST who underwent TAE with Embosphere (R) (n=19) were compared with controls who received cTACE (n=26). The primary end points were treatment response and treatment-related adverse events. The secondary end points were progression-free survival (PFS) and overall survival (OS). Results: The treatment response of Embo-TAE group was significantly higher than that of the cTACE group (P<0.001). The PFS was significantly better in the Embosphere (R)-group than in the cTACE group (56.6 and 42.1 weeks, respectively; P=0.003). However, there was no statistically significant difference in liver toxicity between the two groups (P>0.05). The median OS in the Embo-TAE group was longer than that in the cTACE group (74.0 weeks, 95% CI: 68.2-79.8 vs. 61.7 weeks, 95% CI: 56.2-67.2 weeks) (unadjusted P=0.045). The use of Embo-TAE significantly reduced the risk of death in patients with GIST with liver metastases according to the Cox proportional hazards regression model [hazard ratio (I-M): 0.149; 95% CI: 0.064-0.475]. Conclusions: TAE with Embosphere (R) showed better treatment response and delayed tumor progression compared with cTACE. There was no significant difference in treatment-related hepatic toxicities. Embo-TAE thus appears to be a feasible and promising approach in the treatment of liver metastasis from GIST |
| URI | http://hdl.handle.net/20.500.11897/189600 |
| ISSN | 1000-9604 |
| DOI | 10.3978/j.issn.1000-9604.2014.02.11 |
| Indexed | SCI(E) PubMed 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 北京肿瘤医院 |
