| Title | Amino Acid Polymorphism in the Reverse Transcriptase Region of Hepatitis B Virus and the Relationship With Nucleos(t)ide Analogues Treatment for Preventing Mother-to-Infant Transmission |
| Authors | Chen, Jie Yan, Ling Zhu, Feng-Cai Liu, Jian-Xun Li, Rong-Cheng Wang, Fu-Zhen Li, Jie Zhuang, Hui |
| Affiliation | Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100871, Peoples R China. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100871, Peoples R China. Jiangsu Prov Ctr Dis Control & Prevent, Dept Infect Dis, Nanjing, Jiangsu, Peoples R China. Zhengzhou Municipal Ctr Dis Control & Prevent, Dept Major Projects, Zhengzhou, Peoples R China. Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China. Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | hepatitis B virus reverse transcriptase nucleos(t)ide analogues perinatal transmission ANTIVIRAL RESISTANCE MUTATIONS TREATMENT-NAIVE PATIENTS SURFACE-ANTIGEN PERINATAL TRANSMISSION FAMCICLOVIR RESISTANCE VERTICAL TRANSMISSION POLYMERASE MUTATIONS VACCINATION PROGRAM LAMIVUDINE THERAPY TREATMENT FAILURE |
| Issue Date | 2014 |
| Publisher | 医学病毒学杂志 |
| Citation | JOURNAL OF MEDICAL VIROLOGY.2014,86,(8),1288-1295. |
| Abstract | A high maternal serum hepatitis B virus (HBV) DNA level is associated with vaccine failure. The administration of nucleos(t)ide analogues (NAs) in pregnancy for decreasing serum HBV is regarded as an effective and safe method to reduce HBV perinatal transmission. However, the effect of NAs treatment is closely related to amino acid polymorphisms in the HBV reverse transcriptase (RT) region. The full-length RT coding region of 334 HBV isolates from untreated Chinese women of childbearing age with persistent HBV infection were sequenced and amino acid polymorphic analysis was performed to evaluate its impact on NAs treatment for decreasing HBV perinatal transmission. Of the 334 isolates, 36 (10.8%) harbored NAs resistance (NAr) mutations which were mainly putative drug mutations related to lamivudine. The primary drug mutation rtA181T/V was detected in three HBeAg-negative women with an HBV DNA level of <4 log IU/ml. These NAr mutations were rarely detected in women with an HBV DNA level of >= 7 log IU/ml (P = 0.014) or in women younger than 35 years (P = 0.001). The NAr mutation rate among young women (<35 years) who had a high HBV DNA level (>= 7 log IU/ml) was significantly lower than in women who had lower HBV DNA levels (<7 log IU/ml) or who were older (>= 35 years; P = 0.017). These results suggest that younger women with a high HBV DNA level harbor fewer NAr mutations and that this population may respond to NAs treatment for the prevention of mother-to-infant transmission. (C) 2014 Wiley Periodicals, Inc. |
| URI | http://hdl.handle.net/20.500.11897/189463 |
| ISSN | 0146-6615 |
| DOI | 10.1002/jmv.23948 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
