| Title | Detection and complete genome characterization of human enterovirus 118 from children with acute respiratory disease in China |
| Authors | Lu, Qing-Bin Wo, Ying Wang, Hong-Yu Zhang, Xiao-Ai Huang, Dou-Dou Zhao, Jin Liu, En-Mei Liu, Wei Cao, Wu-Chun |
| Affiliation | Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, 20 Dong Da St, Beijing 100071, Peoples R China. |
| Keywords | Human enterovirus Pneumonia Pediatric China |
| Issue Date | 2014 |
| Publisher | 病毒基因 |
| Citation | VIRUS GENES.2014,48,(3),534-537. |
| Abstract | Enterovirus 118 (EV-118) within species HEV-C was detected in two 5-month-old boys with pneumonia in China. The EV-118 from both cases was genetically closer to ISR10 strain from Israel than to PER161 strain from Peru based on VP1 gene sequences. The complete genome of the detected EV-118 consists of 7,360 nucleotides, excluding the poly (A) tail. The 5'UTR contains 669 nucleotides, and 3'UTR consists of 73 nucleotides. A single open reading frame from base 670 to 7,287 that encodes a 2,206-amino-acid polyprotein was featured. The base composition of the full genome is 27.9 % A, 24.2 % C, 24.4 % G, and 23.6 % U. Phylogenetic analysis of the full genome sequences illustrated EV-118 was genetically closer to EV-109 and EV-105, and the Chinese strain differed from Peru strain. In summary, the presence of EV-118 was confirmed in pediatric pneumonia cases and complete genome sequences were identified for the first time in China. |
| URI | http://hdl.handle.net/20.500.11897/189448 |
| ISSN | 0920-8569 |
| DOI | 10.1007/s11262-014-1044-1 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
