| Title | Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations |
| Authors | Wu, Chen Wang, Zhaoming Song, Xin Feng, Xiao-Shan Abnet, Christian C. He, Jie Hu, Nan Zuo, Xian-Bo Tan, Wen Zhan, Qimin Hu, Zhibin He, Zhonghu Jia, Weihua Zhou, Yifeng Yu, Kai Shu, Xiao-Ou Yuan, Jian-Min Zheng, Wei Zhao, Xue-Ke Gao, She-Gan Yuan, Zhi-Qing Zhou, Fu-You Fan, Zong-Min Cui, Ji-Li Lin, Hong-Li Han, Xue-Na Li, Bei Chen, Xi Dawsey, Sanford M. Liao, Linda Lee, Maxwell P. Ding, Ti Qiao, You-Lin Liu, Zhihua Liu, Yu Yu, Dianke Chang, Jiang Wei, Lixuan Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, |
| Affiliation | Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100730, Peoples R China. Peking Union Med Coll, Beijing 100021, Peoples R China. NCI, Div Canc Epidemiol & Genet, US Natl Inst Hlth, Bethesda, MD 20892 USA. SAIC Frederick Inc, NCI Frederick, Adv Technol Program, Div Canc Epidemiol & Genet,Canc Genome Res Lab, Frederick, MD USA. Xinxiang Med Univ, Basic Med Coll, Canc Res Ctr, Dept Pathol, Xinxiang, Peoples R China. Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou, Peoples R China. Henan Univ Sci & Technol, Affiliated Hosp 1, Clin Lab & Resp Med, Dept Oncol, Luoyang, Peoples R China. Chinese Acad Med Sci, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100730, Peoples R China. Peking Union Med Coll, Beijing 100021, Peoples R China. Anhui Med Univ, Key Lab Dermatol, Hefei, Anhui, Peoples R China. Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China. Peking Univ, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol, Beijing 100871, Peoples R China. Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol Southern China, Guangzhou 510275, Guangdong, Peoples R China. Sun Yat Sen Univ, Ctr Canc, Dept Expt Res, Guangzhou 510275, Guangdong, Peoples R China. Soochow Univ, Coll Med, Lab Canc Mol Genet, Suzhou, Peoples R China. Vanderbilt Univ, Dept Med, Nashville, TN 37235 USA. Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA. Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. Anyang Tumor Hosp, Anyang, Peoples R China. Zhengzhou Univ, Coll Med, Dept Basic Oncol & Pathol, Zhengzhou 450052, Peoples R China. NCI, Ctr Canc Res, US Natl Inst Hlth, Bethesda, MD 20892 USA. Shanxi Canc Hosp, Taiyuan, Peoples R China. Chinese Acad Med Sci, Canc Inst & Hosp, Dept Epidemiol, Beijing 100730, Peoples R China. Peking Union Med Coll, Beijing 100021, Peoples R China. Shanghai Canc Inst, Shanghai, Peoples R China. Duke Natl Univ Singapore, Grad Sch Med, Singapore, Singapore. Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan 430074, Peoples R China. Informat Management Serv Inc, Silver Spring, MD USA. Tumor Hosp Linzhou, Dept Med Oncol, Linzhou, Peoples R China. Cixian Hosp, Ctr Hlth Screening & Endoscopy, Dept Pathol & Thorac Surg, Cixian, Peoples R China. Henan Prov Peoples Hosp, Dept Gastroenterol, Zhengzhou, Peoples R China. Henan Prov Peoples Hosp, Dept Hematol, Zhengzhou, Peoples R China. Henan Prov Peoples Hosp, Cent Lab, Zhengzhou, Peoples R China. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Zhengzhou Univ, Affiliated Hosp 2, Dept Basic Oncol Pathol & Gastroenterol, Zhengzhou 450052, Peoples R China. Nanyang Med Coll, Affiliated Hosp 2, Dept Oncol, Nanyang, Peoples R China. Cent Hosp Xinxiang, Dept Radiotherapy Pathol & Pediat, Xinxiang, Peoples R China. Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250100, Peoples R China. Canc Hosp Henan Prov, Dept Thorac Surg & Radiotherapy, Zhengzhou, Peoples R China. Inner Mongolia Med Coll, Affiliated Hosp, Dept Internal Mongolia Med, Hohhot, Peoples R China. Ningxia Med Univ, Dept Biotechnol, Yinchuan, Peoples R China. Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian, Peoples R China. Sichuan Univ, West China Hosp, Dept Thorac & Cardiovasc Surg, Chengdu 610064, Peoples R China. Shantou Univ, Coll Med, Dept Oncol Pathol, Shantou, Peoples R China. Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou, Peoples R China. Puyang City Oil Field Gen Hosp, Dept Oncol, Puyang, Peoples R China. Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Peoples R China. First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Peoples R China. Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing, Peoples R China. Xinyang Cent Hosp, Dept Oncol, Xinyang, Peoples R China. Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resource & Evolut, Kunming, Peoples R China. Shihezi Univ, Sch Med, Dept Pathol, Shihezi, Peoples R China. Xinjiang Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Urumqi, Peoples R China. Xinjiang Med Univ, Affiliated Hosp 1, Med Res Ctr, Urumqi, Peoples R China. Changzhi Med Univ, Inst Hematol Dis, Changzhi, Peoples R China. Changzhi Med Univ, Dept Pathol, Changzhi, Peoples R China. Hebi Dahejian Hosp, Dept Surg, Hebi, Peoples R China. Anyang Dist Hosp, Anyang, Peoples R China. Fudan Univ, Shanghai Publ Hlth Clin Ctr, Surg Dept, Shanghai 200433, Peoples R China. Second Mil Med Univ Chinese Peoples Liberat Army, Dept Anat, Shanghai, Peoples R China. Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China. Med Coll Wisconsin, Canc Res Ctr, Milwaukee, WI 53226 USA. Chinese Acad Med Sci, Canc Inst & Hosp, Natl Lab Mol Oncol, Beijing 100730, Peoples R China. Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310003, Zhejiang, Peoples R China. Univ Med & Dent New Jersey, Dept Environm & Occupat Hlth, Newark, NJ 07103 USA. |
| Keywords | SUSCEPTIBILITY LOCI RISK VARIANTS CANCER NASOPHARYNGEAL METAANALYSIS LEUKEMIA GLIOMA COHORT PLCE1 |
| Issue Date | 2014 |
| Publisher | nature genetics |
| Citation | NATURE GENETICS.2014,46,(9),1001-+. |
| Abstract | We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS)(1-3) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 x 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 x 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 x 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC. |
| URI | http://hdl.handle.net/20.500.11897/189262 |
| ISSN | 1061-4036 |
| DOI | 10.1038/ng.3064 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
