| Title | Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone |
| Authors | Zhou, Ting Zhao, Lei Zhan, Rui He, Qihua Tong, Yawei Tian, Xiaosheng Wang, Hecheng Zhang, Tao Fu, Yaoyun Sun, Yang Xu, Feng Guo, Xiangyang Fan, Dongsheng Han, Hongbin Chui, Dehua |
| Affiliation | Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China. Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China. Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China. Peking Univ, Ctr Med & Hlth Anal, Beijing 100191, Peoples R China. Peking Univ, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China. Peking Univ, Hosp 3, Beijing 100191, Peoples R China. Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Dapsone Blood-brain barrier integrity Lipopolysaccharide ENDOTHELIAL-CELLS OXIDATIVE STRESS NADPH OXIDASE MOUSE-BRAIN MODEL RATS 4,4'-DIAMINODIPHENYLSULFONE INTEGRITY ISCHEMIA PERMEABILITY |
| Issue Date | 2014 |
| Publisher | 生物化学与生物物理学研究通讯 |
| Citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2014,453,(3),419-424. |
| Abstract | Blood-brain barrier (BBB) dysfunction is a key event in the development of many central nervous system (CNS) diseases, such as septic encephalopathy and stroke. 4,4'-Diaminodiphenylsulfone (DDS, Dapsone) has displayed neuroprotective effect, but whether DDS has protective role on BBB integrity is not clear. This study was designed to examine the effect of DDS on lipopolysaccharide (LPS)-induced BBB disruption and oxidative stress in brain vessels. Using in vivo multiphoton imaging, we found that DDS administration significantly restored BBB integrity compromised by LPS. DDS also increased the expression of tight junction proteins occludin, zona occludens-1 (ZO-1) and claudin-5 in brain vessels. Level of reactive oxygen species (ROS) was reduced by DDS treatment, which may due to decreased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NOX2 expression. Our results showed that LPS-induced BBB dysfunction could be attenuated by DDS, indicated that DDS has a therapeutic potential for treating CNS infection and other BBB related diseases. (C) 2014 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/189076 |
| ISSN | 0006-291X |
| DOI | 10.1016/j.bbrc.2014.09.093 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 第三医院 基础医学院 |
