| Title | Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene |
| Authors | Jiao, Qingqing Liu, Cuiping Yang, Ziliang Ding, Qiang Wang, Miaomiao Li, Min Zhu, Tingting Qian, Hua Li, Wei Tu, Na Fang, Fumin Ye, Licai Zhao, Zuotao Qian, Qihong |
| Affiliation | Soochow Univ, Affiliated Hosp 1, Dept Dermatol, Suzhou 215006, Peoples R China. Soochow Univ, Affiliated Hosp 1, Clin Immunol Lab, Suzhou 215007, Peoples R China. Soochow Univ, Affiliated Childrens Hosp, Dept Dermatol, Suzhou 215003, Peoples R China. Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China. Peking Univ, Dept Dermatol, Hosp 1, 8 Xishenku Rd, Beijing 100034, Peoples R China. |
| Keywords | REVISED CRITERIA AUTOIMMUNITY PATHWAY TOLERANCE SUSCEPTIBILITY CLASSIFICATION |
| Issue Date | 2014 |
| Publisher | international journal of genomics |
| Citation | INTERNATIONAL JOURNAL OF GENOMICS.2014. |
| Abstract | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real-time-reverse transcription polymerase chain reaction (RT-PCR). Also, whether PD-1 expression levels are associated with the variant of the SNP rs36084323 and the SLE Disease Activity Index (SLEDAI) was studied in this work. The PD-1 expression levels of SLE patients were significantly increased compared with those of the healthy controls. The upregulated PD-1 expression levels in SLE patients were greatly associated with SLEDAI scores. No significant difference was found between PD-1 expression levels and SNP rs36084323. The results suggest that increased expression of PD-1 may correlate with the pathogenesis of SLE, upregulated PD-1 expression may be a biomarker for SLE diagnosis, and PD-1 inhibitor may be useful to SLE treatment. |
| URI | http://hdl.handle.net/20.500.11897/189020 |
| ISSN | 2314-436X |
| DOI | 10.1155/2014/950903 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
