| Title | Coinfection with HIV-1 Alleviates Iron Accumulation in Patients with Chronic Hepatitis C Virus Infection |
| Authors | Liu, Yuan Lv, Quanjun Gao, Jian Long, Lu Duan, Zhaojun Liang, Hua Shen, Tao Lu, Fengmin |
| Affiliation | Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100871, Peoples R China. Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Beijing 100871, Peoples R China. Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China. Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China. |
| Keywords | CHRONIC VIRAL-HEPATITIS HEPCIDIN THERAPY DISEASE FERROPORTIN METABOLISM MECHANISMS LIVER HCV |
| Issue Date | 2014 |
| Publisher | plos one |
| Citation | PLOS ONE.2014,9,(6). |
| Abstract | Most chronically-infected hepatitis C virus (HCV) patients have increased levels of iron in the liver. Iron overload reduces sustained responses to antiviral therapy, leading to more rapid progression to liver cirrhosis and the development of hepatocellular carcinoma. However, it is still unclear how HIV-1 infection affects iron status in patients chronically infected with HCV. The present study recruited 227 patients from a village in central China. These patients were either monoinfected with HCV (n = 129) or coinfected with HCV/HIV-1 (n = 98). Healthy controls (n = 84) were also recruited from the same village. Indicators of iron status, such as serum levels of iron, ferritin, and transferrin, total iron-binding capacity (TIBC), transferrin saturation (Tfs), and hepcidin, were analyzed and compared across the three groups. The results showed that serum levels of iron (p = 0.001) and ferritin (p = 0.009) and the Tfs (p = 0.002) were significantly higher in HCV-monoinfected patients than in the healthy controls; however, there were no differences in iron levels and Tfs between HCV/HIV-1 coinfected patients and healthy controls. Additionally, although serum hepcidin levels in HCV-monoinfected and HCV/HIV-1-coinfected patients were lower (p<0.001) than those in health controls, the levels in coinfected patients were higher (p = 0.025) than those in HCV-monoinfected patients. Serum iron and ferritin levels in HCV-monoinfected patients were positively correlated with serum ALT/AST. Serum transferrin levels were negatively correlated with ALT/AST levels. The levels of iron in the serum of coinfected patients with a CD4+T-cell count <500/mu l were lower than those in patients with a CD4+T-cell count >= 500/mu l, whereas serum hepcidin levels showed the opposite trend. Taken together, these results suggest that coinfection with HIV-1 alleviates iron accumulation caused by chronic HCV infection. Our study indicated that determining the status of serum iron and other iron-associated parameters will be helpful to understand the complexity of alternations in iron distribution in HCV/HIV-1-coinfected patients. |
| URI | http://hdl.handle.net/20.500.11897/188959 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0098039 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 医学部待认领 |
