| Title | Exogenous dopamine induces dehydroepiandrosterone sulfotransferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats |
| Authors | Shao Xueyan Li Jian Wang Siyuan Chen Guangping Xu Jiaojiao Ji Xiwei Li Liang Lu Wei Zhou Tianyan |
| Affiliation | Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA. The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: tianyanzhou@bjmu.edu.cn. |
| Keywords | Dehydroepiandrosterone sulfotransferases (SULT2A1),Dopamine,Dopamine receptor,Induction,Liver,Moxifloxacin,Pharmacokinetics |
| Issue Date | 2015 |
| Publisher | drug metabolism and pharmacokinetics |
| Citation | Drug metabolism and pharmacokinetics.2015,30,(1),97-104. |
| Abstract | Dehydroepiandrosterone sulfotransferase (SULT2A1) plays an important role in the detoxification of hydroxyl-containing xenobitotics and in the regulation of the biological activities of hydroxysteroids. Although dopamine (DA) is a vital neurotransmitter, DA also has some special functions in outer peripheral system and takes effect by binding with dopamine receptors including five subtypes (D1-D5). The objective of this study was to investigate the effect of exogenous DA on both the regulation of rSULT2A1 (rat SULT2A1) and the pharmacokinetics of moxifloxacin which is a specific substrate of rSULT2A1. After different doses of DA (0, 2, 10 and 100?mg/kg/d) were administrated to both male and female rats for 7 days, the activity, protein level and mRNA expression of rSULT2A1 increased significantly. Moreover, both Cmax and AUC of moxifloxacin decreased and AUC of moxifloxacin sulfate conjugate metabolite increased significantly when moxifloxacin was administered to rats with DA pretreatment. Additionally, D1 expression in liver and cAMP concentration also increased after the treatment with DA. Overall these results suggest that exogenous DA may induce rSULT2A1 in rat liver and may further change the pharmacokinetic characteristics of some substrates of SULT2A1, and the activation of D1-like receptor is probably involved in rSULT2A1 induction by DA.Copyright ? 2014 The Japanese Society for the Study of Xenobiotics. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/188433 |
| ISSN | 1880-0920 |
| DOI | 10.1016/j.dmpk.2014.10.003 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 天然药物与仿生药物国家重点实验室 药学院 |
