| Title | Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: A cohort study in China |
| Authors | Lu, Qing-Bin Cui, Ning Hu, Jian-Gong Chen, Wei-Wei Xu, Wen Li, Hao Zhang, Xiao-Ai Ly, Hinh Liu, Wei Cao, Wu-Chun |
| Affiliation | Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China. Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China. Peoples Liberat Army, Hosp 302, Beijing 100039, Peoples R China. Univ Minnesota, St Paul, MN 55108 USA. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, 20 Dong Da St, Beijing 100071, Peoples R China. |
| Keywords | Severe fever with thrombocytopenia syndrome Immunological response Cohort study Humoral immunity HEMORRHAGIC-FEVER SYNDROME VIRUS EPIDEMIOLOGY PATHOGENESIS BUNYAVIRUS PROGRESS |
| Issue Date | 2015 |
| Publisher | vaccine |
| Citation | VACCINE.2015,33,(10),1250-1255. |
| Abstract | Background: The immunological responses of patients with severe fever with thrombocytopenia syndrome (SFTS) remain largely unknown. We aim to study the magnitude and sustainability of host immune responses and their correlation with clinical, virological and hematological parameters. Methods: A longitudinal cohort study was performed in a SETS reference hospital. The sequential immunological evaluation was determined for SFTSV infected patients, including anti-SFTSV IgM, IgG antibodies and the lymphocyte subsets. Results: Altogether 298 laboratory-confirmed SFTS cases were analyzed, from whom 55 patients were followed after convalescence. SFTSV specific IgM antibody could be detected at medium of 9 days, surged to peak levels by 4 weeks, and remained persistent until 6 months after disease onset. SFTSV specific IgG antibody could be detected at medium of 6 weeks; surged to peak levels by 6 months, and remained positive in most of the patients even at 3 years after infection. SFTS patients experienced obvious T cell, B cell and NK cells loss during the first week of infection, which was rapidly restored to normal levels. A significantly lower level of humoral immunity was identified concurrently from severe disease, especially in acute phase of the infection. These abnormalities can be used as a potential indicator in the prediction of an adverse clinical outcome. Conclusions: Information gained from this study have clinical significance in enhancing our understanding of SFTS immunological characteristics and the disease pathogenesis. (C) 2015 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/188346 |
| ISSN | 0264-410X |
| DOI | 10.1016/j.vaccine.2015.01.051 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
