| Title | Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions |
| Authors | Yang, Yufei Hu, Mo Yu, Kaiwen Zeng, Xiangmei Liu, Xiaoyun |
| Affiliation | Peking Univ, Coll Chem & Mol Engn, Inst Analyt Chem, Beijing 100871, Peoples R China. Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China. |
| Keywords | mass spectrometry proteomics bacterial infection host-pathogen interactions ENTERICA SEROVAR TYPHIMURIUM EFFECTOR PROTEIN DRRA RAW 264.7 MACROPHAGES SMALL GTPASE RAB1 LEGIONELLA-PNEUMOPHILA SALMONELLA-ENTERICA ESCHERICHIA-COLI IN-VIVO ANAEROBIC GROWTH EXPRESSION |
| Issue Date | 2015 |
| Publisher | protein cell |
| Citation | PROTEIN & CELL.2015,6,(4),265-274. |
| Abstract | Elucidation of molecular mechanisms underlying host-pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells. |
| URI | http://hdl.handle.net/20.500.11897/188266 |
| ISSN | 1674-800X |
| DOI | 10.1007/s13238-015-0136-6 |
| Indexed | SCI(E) PubMed 中国科学引文数据库(CSCD) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
