| Title | Prognostic value of (99m)tc-pertechnetate thyroid scintigraphy in radioiodine therapy in a cohort of chinese graves' disease patients: a pilot clinical study |
| Authors | Hou Haifeng Hu Shu Fan Rong Sun Wen Zhang Xiaofei Tian Mei |
| Affiliation | Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China Zhejiang University Medical PET Center, Hangzhou, Zhejiang 310009, China Institutes of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, Zhejiang 310009, China Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 310009, China. Department of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China. Department of Clinical Epidemiology and Biostatistics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. |
| Issue Date | 2015 |
| Publisher | biomed research international |
| Citation | BioMed research international.2015,2015,974689. |
| Abstract | Objectives. This study is to assess the prognostic value of (99m)Tc-pertechnetate thyroid scintigraphy for predicting the outcomes of fixed low dose of radioiodine therapy (RIT) in a cohort of Chinese Graves' disease (GD) patients. Materials and Methods. This is a retrospective study of GD patients who received RIT with a single dose of radioiodine (5?mCi). All the patients received (99m)Tc-pertechnetate thyroid scintigraphy prior to RIT. Thyroid mass, (99m)Tc-pertechnetate uptake, gender, age at diagnosis, duration of the disease, ophthalmopathy, and serum levels of FT4, FT3, TT4, and TT3 prior to RIT were analyzed as potential interference factors for outcomes of RIT. Results. One hundred and eighteen GD patients who completed RIT were followed up for 12 months. The outcomes (euthyroidism, hypothyroidism, and hyperthyroidism) were found to be significantly associated with thyroid mass and (99m)Tc-pertechnetate uptake. Patients with thyroid mass ≤ 40.1?g or (99m)Tc-pertechnetate uptake ≤ 15.2% had higher treatment success. Conclusions. A fixed low dose of 5?mCi radioiodine seems to be practical and effective for the treatment of Chinese GD patients with thyroid mass ≤ 40.1?g and (99m)Tc-pertechnetate uptake ≤ 15.2%. This study demonstrates (99m)Tc-pertechnetate thyroid scintigraphy is an important prognostic factor for predicting the outcomes of RIT. |
| URI | http://hdl.handle.net/20.500.11897/188083 |
| ISSN | 2314-6141 |
| DOI | 10.1155/2015/974689 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 深圳医院 |
