| Title | The Effects of Needling Fenglong (ST40) and Neiguan (PC6) on IL-17 of ApoE-Gene-Knockout Mice's Liver |
| Authors | Lee, Fu Yun Huo, Ze Jun Zhang, Li Guo, Jia Chen, Huan Liu, Tong Peng, Bo Hong, Pei Xin Peng, Yuan Yuan Fan, Yi Fan Chen, Yu Pei |
| Affiliation | Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, Beijing 100029, Peoples R China. Peking Univ, Acupuncture & Moxibust Dept, Hosp 3, Beijing 100191, Peoples R China. Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, 11 North 3rd Ring Rd, Beijing 100029, Peoples R China. |
| Keywords | LOOP |
| Issue Date | 2014 |
| Publisher | evidence based complementary and alternative medicine |
| Citation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.2014. |
| Abstract | The aim of the present paper was to observe the effects of needling ST40 and PC6 on IL-17 of ApoE(-/-) mice with fatty liver. Forty male ApoE(-/-) mice were randomized into Needling-Acupoint Group, Simvastatin Intragastric Administration Group, Needling Nonacupoint Group, and Model Group. Each was fed with high fat diet for 8 weeks since 16 weeks of age; after 8 weeks of intervention, mice were sacrificed and tested for various examinations. Result showed that the body weight, TC, and serum IL-17 in Needling-Acupoint Group decreased. Compared with Model Group, the immunohistochemical expressions of IL-17 in liver tissue were significantly decreased among the other three groups. In conclusion, acupuncture was able to lower the expression of IL-17 level both in serum and liver tissue in ApoE(-/-) mice, which is helpful to reduce the inflammation and defers the progress from fatty liver to cirrhosis. |
| URI | http://hdl.handle.net/20.500.11897/187820 |
| ISSN | 1741-427X |
| DOI | 10.1155/2014/691863 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
