| Title | Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma |
| Authors | Guo, Xiao-Hong Wang, Jin-Yu Gao, Yan Gao, Min Yu, Guang-Yan Xiang, Ruo-Lan Li, Li Yang, Ning-Yan Cong, Xin Xu, Xiao-Yan Li, Sheng-Lin Peng, Xin Wu, Li-Ling |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Physiol & Pathophysiol, Ctr Salivary Gland Dis,Hlth Sci Ctr, Beijing 100871, Peoples R China. Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China. Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100871, Peoples R China. Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100871, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China. |
| Keywords | MOLECULAR-WEIGHT ADIPONECTIN TYPE-2 DIABETIC-PATIENTS PLASMA ADIPONECTIN SERUM ADIPONECTIN COLORECTAL-CANCER BREAST-CANCER CIRCULATING ADIPONECTIN ENDOMETRIAL CANCER PROSTATE-CANCER GASTRIC-CANCER |
| Issue Date | 2013 |
| Publisher | cancer science |
| Citation | CANCER SCIENCE.2013,104,(2),206-213. |
| Abstract | Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n=37) and western blot (n=30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 +/- 2.4 vs 8.4 +/- 3.5g/mL, P<0.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor-node-metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the TSCC patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of SCC15 cells invitro. These results indicate that a decreased adiponectin level is associated with risk of TSCC. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of TSCC. |
| URI | http://hdl.handle.net/20.500.11897/163098 |
| ISSN | 1347-9032 |
| DOI | 10.1111/cas.12077 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 口腔医院 |
