| Title | Expression and regulation of hedgehog signaling pathway in pancreatic cancer |
| Authors | Yang, Yinmo Tian, Xiaodong Xie, Xuehai Zhuang, Yan Wu, Wenhan Wang, Weimin |
| Affiliation | Peking Univ, Dept Surg, Hosp 1, Beijing 100034, Peoples R China. |
| Keywords | Hedgehog signaling pathway Pancreatic cancer KAAD-cyclopamine SONIC-HEDGEHOG CYCLOPAMINE MUTATIONS GROWTH TUMORIGENESIS CARCINOMAS ACTIVATION MOLECULES SURVIVAL POLARITY |
| Issue Date | 2010 |
| Citation | LANGENBECKS ARCHIVES OF SURGERY.2010,395,(5),515-525. |
| Abstract | Pancreatic cancer is an aggressive malignancy with a poor prognosis. The overall 5-year survival rate of pancreatic cancer is less than 5%, and has not improved significantly for years. Further understanding of the molecular carcinogenesis of pancreatic cancer is critical for designing effective ways to treat this type of malignancy. In this study, we examine expression of hedgehog signaling molecules in 54 surgically removed pancreatic cancer specimens as well as seven available pancreatic cancer cell lines. We find that expression of Ptch is associated with tumor size, tumor differentiation, lymph node metastasis, and clinical stages, whereas expression of Smo is associated with tumor differentiation and lymph node metastasis. Our studies from pancreatic cancer cell lines indicate that targeted inhibition of hedgehog signaling by Smo signaling inhibitor KAAD-cyclopamine causes hedgehog target gene expression (Gli1) suppression, induces P21 expression and G1 cell population, and reduced expression of Cyclin D1 and IGF2. These results indicate that hedgehog signaling activation is a very common event in pancreatic cancer and that targeted inhibition of hedgehog signaling may be effective in treatment of pancreatic cancer. |
| URI | http://hdl.handle.net/20.500.11897/160313 |
| ISSN | 1435-2443 |
| DOI | 10.1007/s00423-009-0493-9 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
