| Title | Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma |
| Authors | Zhang, Junbo He, Xue Ma, Yueying Liu, Yanli Shi, Huaiyin Guo, Weiwei Liu, Liangfa |
| Affiliation | Peking Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100034, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China. Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100050, Peoples R China. Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, 95 Yongan Rd, Beijing 100050, Peoples R China. |
| Keywords | Laryngeal squamous cell carcinoma ROCK Y-27632 tumor growth lymph node metastasis RHO-KINASE IN-VIVO RHO/ROCK PATHWAY CANCER CELLS INVASION TUMOR METASTASIS EXPRESSION MIGRATION PROTEIN |
| Issue Date | 2015 |
| Publisher | international journal of clinical and experimental pathology |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2015,8,(1),244-251. |
| Abstract | Rho-associated coiled-coil containing protein kinase (ROCK) over-expression has been implicated in the progression of many tumor types. The aim of this study was to explore the roles of ROCK1 and ROCK2 in human laryngeal squamous cell carcinoma (LSCC). ROCK1 and ROCK2 expression levels were examined in 50 cases of human LSCC samples by immunohistochemistry. Effects of ROCK1 and ROCK2 on LSCC cell proliferation and motility were investigated in the presence of the ROCK inhibitor Y-27632. The results showed that ROCK1 expression was positively correlated with tumor size and lymph node metastasis (P < 0.05); ROCK2 positively correlated with tumor size (P < 0.05). Inhibition of ROCK1 and ROCK2 by Y-27632 significantly inhibits proliferation, migration, and invasion of LSCC cells. Our data indicate that expression of ROCK1 and ROCK2 are closely associated with tumor growth and lymph node metastasis of LSCC. Thus, these two ROCK isoforms may be useful as molecular makers for LSCC diagnosis and may be useful therapeutic targets as well. |
| URI | http://hdl.handle.net/20.500.11897/159836 |
| ISSN | 1936-2625 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
