| Title | Anti-TNF therapy in patients with HBV infection-analysis of 87 patients with inflammatory arthritis |
| Authors | Ye, Hua Zhang, Xue-wu Mu, Rong Fang, Lin-kai Gu, Jie-ruo Lin, Jin Du, Jin-feng Chen, Jin-wei Chen, Yi-jia Wu, Li-jun Pang, Xue-feng Li, Zhan-guo |
| Affiliation | Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China. Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China. Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China. Xinjiang Autonomous Reg Peoples Hosp, Urumqi, Peoples R China. Guangxi Tradit Chinese Med Univ, Ruikang Hosp, Nanning, Peoples R China. Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, 11 Xizhimen South St Xicheng Dist, Beijing, Peoples R China. |
| Keywords | Etanercept Hepatitis B virus Infliximab Tumor necrosis factor inhibitors NECROSIS-FACTOR-ALPHA B-VIRUS INFECTION CHRONIC HEPATITIS-B REACTIVATION SAFETY AGENTS |
| Issue Date | 2014 |
| Publisher | clinical rheumatology |
| Citation | CLINICAL RHEUMATOLOGY.2014,33,(1),119-123. |
| Abstract | This study aims to investigate the incidence of hepatitis B virus (HBV) reactivation in inflammatory arthritis (IA) patients with HBV infection using anti-tumor necrosis factor (TNF) agents and evaluate the efficacy of antiviral therapy in reducing the risk of viral reactivation in chronic HBV infection. IA patients using anti-TNF agents from six centers were enrolled. Their HBV infection conditions and ALT and HBV-DNA levels were monitored periodically. Among the six chronic hepatitis B patients, HBV reactivation was found in two patients without antivirus prophylaxis and no viral replication was detected in the other four patients with antivirus prophylaxis. In the 31 inactive carriers, the increase of viral load was detected in 6 of 22 (27.3 %) patients without antiviral prophylaxis, and there was no viral reactivation in the other 9 patients with antiviral prophylaxis. HBV reactivation was not found in the 50 patients with resolved HBV infection. It is suggested that anti-TNF therapy might increase the risk of HBV reactivation in patients with chronic HBV infection, and antiviral prophylaxis could effectively decrease the risk. Anti-TNF agents seem to be safe in patients with resolved HBV infection. |
| URI | http://hdl.handle.net/20.500.11897/159680 |
| ISSN | 0770-3198 |
| DOI | 10.1007/s10067-013-2385-1 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
