| Title | A concise synthesis of 4,6-dideoxy-4-base-6-amino-2,5-anhydro-L-mannitols |
| Authors | Wang, Fang Yang, Zhen-Jun Jin, Hong-Wei Zhang, Liang-Ren Zhang, He |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. |
| Keywords | ANTI-HIV AGENTS OLIGONUCLEOTIDES ISONUCLEOSIDES NUCLEOSIDES ANALOGS DNA OLIGODEOXYNUCLEOTIDES TRIPHOSPHATES RECOGNITION DERIVATIVES |
| Issue Date | 2007 |
| Publisher | tetrahedron asymmetry |
| Citation | TETRAHEDRON-ASYMMETRY.2007,18,(18),2139-2146. |
| Abstract | 3,6-Di-O-methanesulfonyl-2,5-anhydro-L-idofuranose dimethyl acetal 9 was reacted with NaN3 in DMF to give 6-azido substituted carbohydrate 10 selectively. A series of 6-amino-isonucleosides 4a-d were synthesized by the reaction of nucleobases with epoxide 13, followed by hydrolysis, reduction, and deprotection, in good yield. (c) 2007 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/157210 |
| ISSN | 0957-4166 |
| DOI | 10.1016/j.tetasy.2007.08.032 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
