| Title | Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry |
| Authors | Han, Jian Ye, Min Qiao, Xue Xu, Man Wang, Bao-rong Guo, De-An |
| Affiliation | Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Xueyuan Rd 38, Beijing 100083, Peoples R China. |
| Keywords | Artemisia annua LC-DAD-ESI-MSn phenolic compounds FLAVONOIDS COMPOSITAE GLYCOSIDE ACIDS DIFFERENTIATION IDENTIFICATION QUADRUPOLE ISOMERS FLOWERS |
| Issue Date | 2008 |
| Publisher | 药学与生物医学分析杂志 |
| Citation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2008,47,(3),516-525. |
| Abstract | A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MSn. A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua. (C) 2008 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/156935 |
| ISSN | 0731-7085 |
| DOI | 10.1016/j.jpba.2008.02.013 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
