| Title | Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells |
| Authors | Wang, Nan Wang, Li-Wen Gou, Bao-Di Zhang, Tian-Lan Wang, Kui |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China. Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China. Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, 38 Xueyuan Rd, Beijing 100083, Peoples R China. |
| Keywords | Realgar Arsenic sulfide Differentiation MAPK pathway HL-60 ACUTE PROMYELOCYTIC LEUKEMIA ACTIVATED PROTEIN-KINASE 1,25-DIHYDROXYVITAMIN D-3-INDUCED DIFFERENTIATION ARSENIC TRIOXIDE RETINOIC ACID SIGNALING PATHWAYS MYELOID-LEUKEMIA HL60 CELLS IN-VITRO INHIBITOR |
| Issue Date | 2008 |
| Publisher | cell biology international |
| Citation | CELL BIOLOGY INTERNATIONAL.2008,32,(12),1497-1505. |
| Abstract | The clinical efficacy and safety of realgar (arsenic sulfide, As(4)S(4)) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL-60 cells. Treatment with RNPs at 6 mu M for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP-induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP-induced differentiation in HL-60 cells. (c) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/156844 |
| ISSN | 1065-6995 |
| DOI | 10.1016/j.cellbi.2008.08.017 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 药学院 |
