| Title | Total Synthesis of (+/-)-Decursivine and (+/-)-Serotobenine: A Witkop Photocyclization/Elimination/O-Michael Addition Cascade Approach |
| Authors | Qin, Hua Xu, Zhengren Cui, Yuxin Jia, Yanxing |
| Affiliation | Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China. Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Xue Yuan Rd 38, Beijing 100191, Peoples R China. |
| Keywords | cascade reaction cyclization natural products photochemistry total synthesis PROTECTING-GROUP-FREE EFFICIENT TOTAL-SYNTHESIS 3,4-BRIDGED INDOLES METHYL-ESTER DERIVATIVES TRYPTOPHAN ACID CATALYSIS ANALOGS YIELDS |
| Issue Date | 2011 |
| Publisher | angewandte chemie international edition |
| Citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.2011,50,(19),4447-4449. |
| Abstract | A photo op: The concise total syntheses of (??)-decursivine and (??)-serotobenine were achieved by using the titled cascade reaction, which is modeled on the biomimetic pathway. The synthesis of (??)-decursivine, which exhibits antimalarial activity, was carried out in five steps without using protecting groups. Copyright ? 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| URI | http://hdl.handle.net/20.500.11897/156694 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.201100495 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
