| Title | DHA-rich marine microalga Schizochytrium mangrovei possesses anti-ageing effects on Drosophila melanogaster |
| Authors | Huangfu, Jieqiong Liu, Jin Peng, Cheng Suen, Yung Lee Wang, Mingfu Jiang, Yue Chen, Zhen-Yu Chen, Peng |
| Affiliation | Peking Univ, Coll Engn, Inst Food & Bioresource Engn, Beijing 100871, Peoples R China. Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China. Arizona State Univ, Dept Appl Sci & Math, Mesa, AZ 85212 USA. Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Hong Kong, Peoples R China. Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China. |
| Keywords | Ageing Microalgae Schizochytrium mangrovei Drosophila melanogaster Stress-defense DOCOSAHEXAENOIC ACID ALZHEIMERS-DISEASE LIFE-SPAN LIPID-METABOLISM OIL PREVENTION MUTANT CELLS |
| Issue Date | 2013 |
| Publisher | journal of functional foods |
| Citation | JOURNAL OF FUNCTIONAL FOODS.2013,5,(2),888-896. |
| Abstract | Docosahexaenoic acid (DHA) play important roles in the prevention of ageing and ageing-related diseases. In this work, the anti-ageing effect of Schizochytrium mangrovei (SM), a marine microalga with high contents of DHA was investigated for the first time. In vitro results showed that SM enhanced the vitality of healthy pheochromocytoma (PC12) cells, whereas it had no protective effect under H2O2-induced oxidative stress. Meanwhile, SM exerted neuroprotective actions in vivo: the supplementation of SM significantly extended the lifespan of both wild type and SODn108 mutant flies Drosophila melanogaster, and ameliorated the age-related decline of locomotor function. This lifespan-extending activity was associated with the mRNA up-regulation of endogenous stress-defense genes such as CuZn-superoxide dismutase (SOD1) and Mn-superoxide dismutase (SOD2), as well as the down-regulation of Methuselah (MTH) gene. Therefore, it was concluded that the anti-ageing capability of DHA-rich SM was mediated through the cooperation with endogenous stress-defense system rather than the direct interaction with oxidative free radicals. (C) 2013 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/154494 |
| ISSN | 1756-4646 |
| DOI | 10.1016/j.jff.2013.01.038 |
| Indexed | SCI(E) |
| Appears in Collections: | 工学院 |
