| Title | Antiaging Effects of Astaxanthin-Rich Alga Haematococcus pluvialis on Fruit Flies under Oxidative Stress |
| Authors | Huangfu, Jieqiong Liu, Jin Sun, Zheng Wang, Mingfu Jiang, Yue Chen, Zhen-Yu Chen, Feng |
| Affiliation | Peking Univ, Coll Engn, Inst Food & Bioresource Engn, Beijing 100871, Peoples R China. Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China. Univ Maryland, Ctr Environm Sci, Inst Marine & Environm Technol, Baltimore, MD 21201 USA. Jiangnan Univ, Sch Food Sci, Wuxi, Peoples R China. Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Hong Kong, Peoples R China. |
| Keywords | aging microalgae Haematococcus pluvialis antioxidant astaxanthin Drosophila melanogaster LIFE-SPAN DROSOPHILA-MELANOGASTER METABOLISM CHEMISTRY BENEFITS |
| Issue Date | 2013 |
| Publisher | 农业化学与食品化学杂志 |
| Citation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2013,61,(32),7800-7804. |
| Abstract | The microalga Haematococcus pluvialis (HP) is the best natural producer of astaxanthin (AX), which is a potent antioxidant with broad health benefits. The present study investigated the antiaging potential of HP biomass using the fruit fly Drosophila melanogaster as the animal model. The results showed that in wild-type flies the treatment of HP induced the early mortality at a concentration of 20 mg/mL, which was associated with the decreased enzymatic activities of CuZn-superoxide dismutase (SOD1) and Mn-superoxide dismutase (SOD2) as well as the down-regulation of SOD 1, SOD2, and catalase (CAT) at the transcriptional level. In SODn108 mutant flies, the supplementation of HP (10 or 20 mg/mL) significantly extended their lifespan and ameliorated the age-related decline in locomotor function. Further studies suggested that HP may play a role as a complement to the defective endogenous antioxidant system to exert such lifespan elongation effects. These results, taken together, strongly support the antiaging properties of HP and its therapeutic rather than preventive potential against aging-related diseases. |
| URI | http://hdl.handle.net/20.500.11897/153920 |
| ISSN | 0021-8561 |
| DOI | 10.1021/jf402224w |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 工学院 |
