| Title | Binding Assistance Triggering Attachments of Hairpin DNA onto Gold Nanoparticles |
| Authors | Zhang, Cheng Ma, Jingjing Yang, Jing Liu, Shi Xu, Jin |
| Affiliation | Peking Univ, Sch Elect Engn & Comp Sci, Key Lab High Confidence Software Technol, Minist Educ,Inst Software, Beijing 100871, Peoples R China. North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China. |
| Keywords | BUILDING-BLOCKS RATIONAL DESIGN ARRAYS MOTOR HYBRIDIZATION GROUPINGS SCAFFOLDS SHAPES ENZYME |
| Issue Date | 2013 |
| Publisher | analytical chemistry |
| Citation | ANALYTICAL CHEMISTRY.2013,85,(24),11973-11978. |
| Abstract | Here, we present a strategy to trigger monovalent attachments of thoilated hairpin DNA onto AuNP, assisted by molecular binding. Without binding helper strands, it is hard to control the attachments of thiolated hairpin DNA, because of spatial hindrances. By introducing a binding helper strand, the thiol-group can be brought into close proximity to the surface of AuNPs, which will greatly increase the local molecular concentration and attaching efficiency. In the experiments, the strategy is verified by the methods of DNA strand branch migration and dynamic assembly of AuNPs clusters. In addition, unique and complex AuNPs clusters with well-defined arrangements of DNA scaffolds are produced. Using this method, it is able to selectively manipulate and control different kinds and numbers of DNA attaching onto AuNPs. Our strategy also could be extended to assembling large complicated DNA/AuNPs programmable structures and nanodevices. |
| URI | http://hdl.handle.net/20.500.11897/151799 |
| ISSN | 0003-2700 |
| DOI | 10.1021/ac402908y |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 信息科学技术学院 高可信软件技术教育部重点实验室 |
