| Title | Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten |
| Authors | Sun, Nijuan McMullan, Martin Papakonstantinou, Pagona Gao, Hui Zhang, Xinxiang Mihailovic, Dragan Li, Meixian |
| Affiliation | Univ Ulster, Nanotechnol & Integrated Bioengn Ctr, Newtownabbey BT37 0QB, Antrim, North Ireland. Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China. Jozef Stefan Inst, SI-1000 Ljubljana, Slovenia. |
| Keywords | TANDEM MASS-SPECTROMETRY MO6S4.5I4.5 NANOWIRES GAS-CHROMATOGRAPHY ESTROGENS PROTEIN WATER NANOSENSORS EXTRACTION ELECTRODE MO6S3I6 |
| Issue Date | 2008 |
| Publisher | analytical chemistry |
| Citation | ANALYTICAL CHEMISTRY.2008,80,(10),3593-3597. |
| Abstract | We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range. |
| URI | http://hdl.handle.net/20.500.11897/150235 |
| ISSN | 0003-2700 |
| DOI | 10.1021/ac7024893 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
