| Title | Rhodium/Copper-Catalyzed Annulation of Benzimides with Internal Alkynes: Indenone Synthesis through Sequential C-H and C-N Cleavage |
| Authors | Li, Bi-Jie Wang, Hao-Yuan Zhu, Qi-Lei Shi, Zhang-Jie |
| Affiliation | Peking Univ, BNLMS, Minist Educ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China. Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China. Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China. Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China. |
| Keywords | annulation C?H activation heterocycles rhodium synthetic methods CARBONYLATIVE CYCLIZATION REACTIONS CARBON-HYDROGEN BONDS DIRECT ARYLATION ARYL-KETONES NUCLEOPHILIC-SUBSTITUTION UNSATURATED MOLECULES ASYMMETRIC-SYNTHESIS AROMATIC KETIMINES ORGANIC-SYNTHESIS DIRECTING GROUP |
| Issue Date | 2012 |
| Publisher | angewandte chemie international edition |
| Citation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.2012,51,(16),3948-3952. |
| Abstract | Doubled up: a rhodium(III)/copper(II) system co-catalyzes the annulation of benzimides with internal alkynes for the synthesis of indenones (see scheme; Cp*=C(5) Me(5)). The reaction involves an uncommon nucleophilic addition of a transition-metal-carbon bond to an imide moiety. This novel reaction provides a facile route to synthesize indenones from readily available benzimides and internal alkynes.Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| URI | http://hdl.handle.net/20.500.11897/149908 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.201200271 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
