开云app体育 讲席教授
未来技术学院院长
《新英格兰医学杂志》副主编
国家杰出青年基金获得者
个人简介
长期从事心血管及代谢疾病的基础和转化研究。在Nature、Nature Medicine、Nature Cell Biology、Molecular Cell、Circulation等杂志发表论文160余篇，引用超过11,000次。获得2015年ISHR President Lecture Award。从2014年起，担任《新英格兰医学杂志》副主编。担任美国心脏学会中大西洋地区指导委员会委员，国际心脏学会(ISHR)理事，以及美国临床医学研究会会士。
所授课程
《分子医学高级教程》（必修，3学分）
《生理学》（必修，3学分）
《心血管代谢病理生理》（选修，3学分）
《心血管药理》（选修，3学分）
教育背景
1979-1984 同济医科大学 （学士学位）
1985-1987同济医科大学，生理学系 （硕士学位）
1987-1988 开云app体育 生物系，博士研究生
1991-1995 美国马里兰大学医学院，生理学系，（博士学位）
工作简历
1988-1989 波多黎各大学医学院，博士后
1990-1991 美国NIH心血管研究室，博士后
1992-1996 美国NIH/NIA心血管研究室, Staff Scientist
1996-2003 美国NIH/NIA心血管研究室, 研究员 （Unit Head）
2003-2010 美国NIH/NIA心血管研究室, 资深研究员（with tenure, Section Head）
承担项目
n 国家重点研发计划 (子课题负责人，项目编号2018YFA0507603，“代谢疾病及其心血管并发症中蛋白质糖基化的功能研究”，本人负责317.8万，2018.05-2023.12)
n 国家自然科学基金重大项目 (子课题负责人，项目编号81790621，“花生四烯酸代谢小分子在心肌重构进展中的变化规律及机制”，本人负责450万，2018.01-2022.12)
n 国家自然科学基金重点项目 (课题负责人，项目编号81630008，“Beta-arrestin在心脏损伤和心衰中的作用及其机制研究“，263万，2017.01-2021.12)
代表性论文
1. Peng Jiang#, Lejiao Ren L#, Li Zhi#, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu*, Rui-Ping Xiao*. Negative Regulation of AMPK Signaling by High Glucose via E3 Ubiquitin Ligase MG53. Molecular Cell, 2021, 81(3):629-637.
2. Dan Shan#, Sile Guo#, Hong-Kun Wu, Fengxiang Lv, Li Jin L, Mao Zhang, Peng Xie, Yimei Wang, Ying Song, Wu F, Lan F, Hu X, Cao CM*, Zhang Y*, Rui-Ping Xiao*. Cardiac Ischemic Preconditioning Promotes MG53 Secretion through H2O2-activated PKC-d Signaling. Circulation, 2020, 142(11):1077-1091.
3. Ying Song, Chanjuan Xu, Jianfeng Liu, Yulong Li, Huan Wang, Dan Shan, Irving W. Wainer, Xinli Hu, Yan Zhang*, Anthony Yiu-Ho Woo*, Rui-Ping Xiao. Heterodimerization with 5-HT2BR Is Indispensable for β2AR-mediated Cardioprotection. Circulation Research, 2020, 128(2):262-277.
4. Mao Zhang, Hua Gao, Dairu Liu, Xiaoming Zhong, Xiaolu Shi, Peng Yu, Li Jin, Yun Liu, Yajie Tang, Yunhu Song, Jinghao Liu, Xinli Hu, Chuan-Yun Li, Lei Song, Jun Qin, Fujian Wu, Feng Lan, Yan Zhang, Rui-Ping Xiao. CaMKII-d9 Promotes Cardiomyopathy through Disrupting UBE2T-dependent DNA Repair. Nature Cell Biology, 2019, 21:1152-1163.
5. Hong-Kun Wu #, Yan Zhang#, Chun-Mei Cao#, Xinli Hu, Meng Fang, YuanYao, Li Jin, Gengjia Chen, Peng Jiang, Shuo Zhang, Ruisheng Song, Wei Peng, Fenghua Liu, Jiaojiao Guo, Lifei Tang, Yanyun He, Dan Shan, Jin Huang, Zhou Zhou, Dao Wen Wang, Fengxiaong Lv*, Rui-Ping Xiao*. Glucose-sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis. Circulation, 2019, 139:901–914.
6. Yao Xiao#, Can Wang#, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li*, and Xiuqin Zhang*. Deficiency of PRKD2 Triggers Hyperinsulinemia and Metabolic Disorders. Nature Communication, 2018, 9(1): 2015.
7. Ting Zhang#, Yang Zhang #*, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen Zheng, Haibao Shang, Jun Zhang, Mao Zhang, Hongkun Wu, Jiaojiao Guo, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao*, Rui-Ping Xiao*. CaMKII Is A RIP3 Substrate Mediating Ischemia- and Oxidative Stress-Induced Myocardial Necroptosis. Nature Medicine, 2016, 22(2): 175-182.
8. Weizhong Zhu, Sharon Tsang, David M Browe, Anthony Yh Woo, Ying Huang, Chanjuan Xu, Jian-Feng Liu, Fengxiang Lv, Yan Zhang*, Rui-Ping Xiao*. Interaction of β1-Adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling. JCI Insight, 2016, 1(1): e84969.
9. Fenghua Liu#, Ruisheng Song#, Yuanqing Feng#, Jiaojiao Guo, Yanmin Chen, Yong Zhang, Tao Chen, Yanru Wang, Yanyi Huang, Chuan-Yun Li, Chunmei Cao, Yan Zhang, Xinli Hu*, Rui-Ping Xiao*. Upregulation of MG53 Induces Diabetic Cardiomyopathy through Transcriptional Activation of Peroxisome Proliferation-Activated Receptor α. Circulation, 2015, 131(9): 795-804.
10. Ruisheng Song, Wei Peng, Yan Zhang, Fengxiang Lv, Hong-Kun Wu, Jiaojiao Guo, Yongxing Cao, Yanbin Pi, Xin Zhang, Li Jin, Mao Zhang, Peng Jiang, Fenghua Liu, Shaoshuai Meng, Xiuqin Zhang, Ping Jiang, Chun-Mei Cao*, Rui-Ping Xiao*. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature, 2013, 494(7437): 375-379.